Neuroethics Resources
OpenMind Neuroethics Update - 2024
Online references & publications:
Selected Scholarly Publications
Continuing trial responsibilities for implanted neural devices
Hendriks S, Hsu N, Beckel-Mitchener AC, Ngai J, Grady C. Continuing trial responsibilities for implantable neural devices. Neuron. 2023 Oct 18;111(20):3143-3149. doi: 10.1016/j.neuron.2023.07.008. Epub 2023 Aug 14. PMID: 37582365.
The mystery of mental integrity: Clarifying its relevance to neural technologies
Zohny H, Lyreskog DM, Singh I, Savulescu J. The Mystery of Mental Integrity: Clarifying Its Relevance to Neurotechnologies. Neuroethics. 2023;16(3):20. doi: 10.1007/s12152-023-09525-2. Epub 2023 Aug 21. PMID: 37614938; PMCID: PMC10442279.
Hope and optimism in pediatric deep brain stimulation: Key stakeholder perspectives
Dorfman N, Snellman L, Kerley Y, Kostick-Quenet K, Lazaro-Munoz G, Storch EA, Blumenthal-Barby J. Hope and Optimism in Pediatric Deep Brain Stimulation: Key Stakeholder Perspectives. Neuroethics. 2023 Oct;16(3):17. doi: 10.1007/s12152-023-09524-3. Epub 2023 Aug 1. PMID: 37905206; PMCID: PMC10615366.
Neuroscience and society: Supporting and unsettling public engagement
Kaebnick GE. Neuroscience and Society: Supporting and Unsettling Public Engagement. Hastings Cent Rep. 2024 Jan;54(1):20-23. doi: 10.1002/hast.1565. PMID: 38390680.
Adolescent OCD patient and caregiver perspectives on identity, authenticity, and normalcy in potential deep brain stimulation treatment
Smith JN, Dorfman N, Hurley M, Cenolli I, Kostick-Quenet K, Storch EA, Lázaro-Muñoz G, Blumenthal-Barby J. Adolescent OCD Patient and Caregiver Perspectives on Identity, Authenticity, and Normalcy in Potential Deep Brain Stimulation Treatment. Camb Q Healthc Ethics. 2024 Apr 11:1-14. doi: 10.1017/S0963180124000203. Epub ahead of print. PMID: 38602092.
Definition of implanted neurological device abandonment: A systematic review and consensus statement
Okun MS, Marjenin T, Ekanayake J, Gilbert F, Doherty SP, Pilkington J, French J, Kubu C, Lázaro-Muñoz G, Denison T, Giordano J. Definition of Implanted Neurological Device Abandonment: A Systematic Review and Consensus Statement. JAMA Netw Open. 2024 Apr 1;7(4):e248654. doi: 10.1001/jamanetworkopen.2024.8654. PMID: 38687486.
Deep brain stimulation and suicide attempts in treatment-resistant patients: a case report and neuroethical analysis
D'Imperio A, Ienca M. Deep brain stimulation and suicide attempts in treatment-resistant patients: a case report and neuroethical analysis. Front Psychiatry. 2024 Jun 26;15:1398777. doi: 10.3389/fpsyt.2024.1398777. PMID: 38988738; PMCID: PMC11234500.
Deep brain stimulation for consciousness disorders; technical and ethical considerations
Deli A, Green AL. Deep Brain Stimulation for Consciousness Disorders; Technical and Ethical Considerations. Neuroethics. 2024;17(3):35. doi: 10.1007/s12152-024-09570-5. Epub 2024 Jul 30. PMID: 39091894; PMCID: PMC11289033.
Proceedings of the 11th Annual Deep Brain Stimulation Think Tank : pushing the forefront of neuromodulation with functional network mapping, biomarkers for adaptive DBS, bioethical dilemas, AI-guided neuromodulation, and translational advancements
Johnson KA, Dosenbach NUF, Gordon EM, Welle CG, Wilkins KB, Bronte-Stewart HM, Voon V, Morishita T, Sakai Y, Merner AR, Lázaro-Muñoz G, Williamson T, Horn A, Gilron R, O'Keeffe J, Gittis AH, Neumann WJ, Little S, Provenza NR, Sheth SA, Fasano A, Holt-Becker AB, Raike RS, Moore L, Pathak YJ, Greene D, Marceglia S, Krinke L, Tan H, Bergman H, Pötter-Nerger M, Sun B, Cabrera LY, McIntyre CC, Harel N, Mayberg HS, Krystal AD, Pouratian N, Starr PA, Foote KD, Okun MS, Wong JK. Front Hum Neurosci. 2024 Feb 21;18:1320806. doi: 10.3389/fnhum.2024.1320806. PMID: 38450221; PMCID: PMC10915873.
OpenMind Neuroethics Update - 2023
Online references & publications:
Journalism
“Neurotech DIY: Fixing Your Own Implant — As the Neurotechnology Market Expands, What Happens to those Left Behind”?
(Dan Fox, Nature, June 2023)
Selected Scholarly Publications
Merner AR, Kostick-Quenet K, Campbell TA, Pham MT, Sanchez CE, Torgerson L, Robinson J, Pereira S, Outram S, Koenig BA, Starr PA, Gunduz A, Foote KD, Okun MS, Goodman W, McGuire AL, Zuk P, Lázaro-Muñoz G. Participant perceptions of changes in psychosocial domains following participation in an adaptive deep brain stimulation trial. Brain Stimul. 2023 Jun 15;16(4):990-998. doi: 10.1016/j.brs.2023.06.007. Epub ahead of print. PMID: 37330169.
Boulicault M, Goering S, Klein E, Dougherty D, Widge AS. The Role of Family Members in Psychiatric Deep Brain Stimulation Trials: More Than Psychosocial Support. Neuroethics. 2023;16(2):14. doi: 10.1007/s12152-023-09520-7. Epub 2023 May 26. PMID: 37250273; PMCID: PMC10212803.
Hitti FL, Widge AS, Riva-Posse P, Malone DA Jr, Okun MS, Shanechi MM, Foote KD, Lisanby SH, Ankudowich E, Chivukula S, Chang EF, Gunduz A, Hamani C, Feinsinger A, Kubu CS, Chiong W, Chandler JA, Carbunaru R, Cheeran B, Raike RS, Davis RA, Halpern CH, Vanegas-Arroyave N, Markovic D, Bick SK, McIntyre CC, Richardson RM, Dougherty DD, Kopell BH, Sweet JA, Goodman WK, Sheth SA, Pouratian N. Future directions in psychiatric neurosurgery: Proceedings of the 2022 American Society for Stereotactic and Functional Neurosurgery meeting on surgical neuromodulation for psychiatric disorders. Brain Stimul. 2023 May-Jun;16(3):867-878. doi: 10.1016/j.brs.2023.05.011. Epub 2023 May 20. PMID: 37217075.
Wong JK, Mayberg HS, Wang DD, Richardson RM, Halpern CH, Krinke L, Arlotti M, Rossi L, Priori A, Marceglia S, Gilron R, Cavanagh JF, Judy JW, Miocinovic S, Devergnas AD, Sillitoe RV, Cernera S, Oehrn CR, Gunduz A, Goodman WK, Petersen EA, Bronte-Stewart H, Raike RS, Malekmohammadi M, Greene D, Heiden P, Tan H, Volkmann J, Voon V, Li L, Sah P, Coyne T, Silburn PA, Kubu CS, Wexler A, Chandler J, Provenza NR, Heilbronner SR, Luciano MS, Rozell CJ, Fox MD, de Hemptinne C, Henderson JM, Sheth SA, Okun MS. Proceedings of the 10th annual deep brain stimulation think tank: Advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics, interventional psychiatry, and women in neuromodulation. Front Hum Neurosci. 2023 Jan 27;16:1084782. doi: 10.3389/fnhum.2022.1084782. PMID: 36819295; PMCID: PMC9933515.
Straw I, Ashworth C, Radford N. When brain devices go wrong: a patient with a malfunctioning deep brain stimulator (DBS) presents to the emergency department. BMJ Case Rep. 2022 Dec 26;15(12):e252305. doi: 10.1136/bcr-2022-252305. PMID: 36572446; PMCID: PMC9806045.
Schönau A, Goering S, Versalovic E, Montes N, Brown T, Dasgupta I, Klein E. Asking questions that matter - Question prompt lists as tools for improving the consent process for neurotechnology clinical trials. Front Hum Neurosci. 2022 Jul 29;16:983226. doi: 10.3389/fnhum.2022.983226. PMID: 35966997; PMCID: PMC9372354.
OpenMind Neuroethics Update - 2022
Online references & publications:
Journalism
Long-term Device Support for Study Participants & Technology Users
“Their Bionic Eyes are Now Obsolete and Unsupported” (Eliza Strickland & Mark Harris, IEEE Spectrum, Feb 2022)
https://spectrum.ieee.org/bionic-eye-obsolete
Note on this topic: Resources related to the NIH BRAIN Initiative Workshop, “Continuing Trial Responsibilities” (May 2022) may be found here:
May 24-25, 2022 meeting agenda(PDF, 195KB)
May 24-25, 2022 meeting summary(PDF, 416KB)
Neuroethics Projects
BRAIN Initiative Neuroethics Working Group
Representing a component of the neuroethics efforts of the NIH BRAIN Initiative, the Neuroethics Working Group is a group of experts in neuroethics and neuroscience that serves to provide the NIH BRAIN Initiative with input relating to neuroethics.
https://braininitiative.nih.gov/about/neuroethics-working-group
NEWG areas of activity include:
Identify ethical challenges in the development and/or application of BRAIN Initiative-funded tools and technologies.
Anticipate ethical challenges in proposed areas of BRAIN Initiative funding.
Provide input on ways The BRAIN Initiative could navigate these neuroethics challenges.
Provide ethics consultation to researchers funded by The BRAIN Initiative, when appropriate.
Identify neuroethics research questions important to The BRAIN Initiative that could be addressed through focused Funding Opportunity Announcements
Publish guidance on key ethical challenges associated with BRAIN Initiative-funded research.
IEEE BRAIN Neuroethics Framework
Contact: Dr. Laura Cabrera, lcabrera@psu.edu
The IEEE Brain Neuroethics Subcommittee is developing a neuroethical framework for evaluating the ethical, legal, social, and cultural issues that may arise with the deployment of such neurotechnologies:
Further information may be found here:
https://brain.ieee.org/wp-content/uploads/2021/10/ieee_brain_neuroethics_flyer_OCT2021.pdf
Selected Scholarly Publications
Researchers' Ethical Concerns About Using Adaptive Deep Brain Stimulation for Enhancement.
Kostick-Quenet K, Kalwani L, Koenig B, Torgerson L, Sanchez C, Munoz K, Hsu RL, Sierra-Mercado D, Robinson JO, Outram S, Pereira S, McGuire A, Zuk P, Lazaro-Munoz G. Front Hum Neurosci. 2022 Apr 14;16:813922. doi: 10.3389/fnhum.2022.813922. eCollection 2022. PMID: 35496073
Highly recommended: Ethical commitments, principles, and practices guiding intracranial neuroscientific research in humans.
Feinsinger A, Pouratian N, Ebadi H, Adolphs R, Andersen R, Beauchamp MS, Chang EF, Crone NE, Collinger JL, Fried I, Mamelak A, Richardson M, Rutishauser U, Sheth SA, Suthana N, Tandon N, Yoshor D; NIH Research Opportunities in Humans Consortium. Neuron. 2022 Jan 19;110(2):188-194. doi: 10.1016/j.neuron.2021.11.011. PMID: 35051364
Projections and the Potential Societal Impact of the Future of Neurotechnologies.
Gaudry KS, Ayaz H, Bedows A, Celnik P, Eagleman D, Grover P, Illes J, Rao RPN, Robinson JT, Thyagarajan K; Working Group on Brain-Interfacing Devices in 2040. Front Neurosci. 2021 Nov 15;15:658930. doi: 10.3389/fnins.2021.658930. eCollection 2021.PMID: 34867139
Chiang S, Picard RW, Chiong W, Moss R, Worrell GA, Rao VR, Goldenholz DM. Neurology. 2021 Sep 28;97(13):632-640. doi: 10.1212/WNL.0000000000012570. Epub 2021 Jul 27. PMID: 34315785
Recommendations for Responsible Development and Application of Neurotechnologies.
Goering S, Klein E, Specker Sullivan L, Wexler A, Agüera Y Arcas B, Bi G, Carmena JM, Fins JJ, Friesen P, Gallant J, Huggins JE, Kellmeyer P, Marblestone A, Mitchell C, Parens E, Pham M, Rubel A, Sadato N, Teicher M, Wasserman D, Whittaker M, Wolpaw J, Yuste R. Neuroethics. 2021;14(3):365-386. doi: 10.1007/s12152-021-09468-6. Epub 2021 Apr 29. PMID: 33942016
Mapping the Dimensions of Agency.
Schönau A, Dasgupta I, Brown T, Versalovic E, Klein E, Goering S. AJOB Neurosci. 2021 Apr-Sep;12(2-3):172-186. doi: 10.1080/21507740.2021.1896599. Epub 2021 Mar 25. PMID: 33764258
Vedam-Mai V, Deisseroth K, Giordano J, Lazaro-Munoz G, Chiong W, Suthana N, Langevin JP, Gill J, Goodman W, Provenza NR, Halpern CH, Shivacharan RS, Cunningham TN, Sheth SA, Pouratian N, Scangos KW, Mayberg HS, Horn A, Johnson KA, Butson CR, Gilron R, de Hemptinne C, Wilt R, Yaroshinsky M, Little S, Starr P, Worrell G, Shirvalkar P, Chang E, Volkmann J, Muthuraman M, Groppa S, Kühn AA, Li L, Johnson M, Otto KJ, Raike R, Goetz S, Wu C, Silburn P, Cheeran B, Pathak YJ, Malekmohammadi M, Gunduz A, Wong JK, Cernera S, Hu W, Wagle Shukla A, Ramirez-Zamora A, Deeb W, Patterson A, Foote KD, Okun MS. Front Hum Neurosci. 2021 Apr 19;15:644593. doi: 10.3389/fnhum.2021.644593. eCollection 2021. PMID: 33953663
New Ethical and Clinical Challenges in "Closed-Loop" Neuromodulation.
Hegde M, Chiong W, Rao VR. Neurology. 2021 Apr 27;96(17):799-804. doi: 10.1212/WNL.0000000000011834. Epub 2021 Mar 16. PMID: 33727407
Versalovic E, Diamond M, Klein E. Disabil Rehabil Assist Technol. 2020 Sep 17:1-8. doi: 10.1080/17483107.2020.1817991. Online ahead of print. PMID: 32940119
Ethics and the emergence of brain-computer interface medicine.
Klein E. Handb Clin Neurol. 2020;168:329-339. doi: 10.1016/B978-0-444-63934-9.00024-X. PMID: 32164863